The factors causing disability after SCI include axonal degeneration, losing of neurons, abnormal activation of immune cells, etc. Spinal cord injury (SCI), a serious trauma of the central nervous system, is characterized by high morbidity and high disability rate. Low temperature extrusion 3D printing, brain-derived neurotrophic factor, collagen, chitosan, diffusion tensor imaging, spinal cord injury Introduction Consistent with the recovery of locomotor function, 3D-CC-BDNF treatment could fill the gap, facilitate nerve fiber regeneration, accelerate the establishment of synaptic connections and enhance remyelination at the injury site.
Eight weeks after the implantation of scaffolds in the transected lesion of T10 of the spinal cord, 3D-CC-BDNF significantly ameliorate locomotor function of the rats. In this study, we developed a collagen/chitosan scaffold integrated with brain-derived neurotrophic factor (3D-CC-BDNF) by low temperature extrusion 3D printing as a new type of artificial controlled release system, which could prolong the release of BDNF for the treatment of spinal cord injury (SCI). Low temperature 3D printing can incorporate growth factors into the scaffold and maintain their biological activity.
However, heat, organic solvents or cross-linking agents used in conventional 3D printing reduce the biological activity of growth factors. Recent studies have shown that 3D printed scaffolds integrated with growth factors can guide the growth of neurites and promote axon regeneration at the injury site.
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